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Cheap flights from Madrid, Spain to Santa Cruz de la Sierra from £406

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 16/5. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
23 Apr — 30 Apr1
1 adult

Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in May or March, booked 68 days in advance, depart on a Thursday or Tuesday and return on a Monday

Cheap flight deals from Madrid to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 18 April 2025.

Round-trip from

£702

One-way from

£406

Popular in

December

Cheapest in

May

Average price

£668
Avianca
  • Avianca
  • 6/6-12/6
  • 2 total stops
  • 44h 55m total
  • Madrid to Santa Cruz de la Sierra
Search Deals
BoA
  • BoA
  • 16/5
  • Nonstop
  • 11h 30m total
  • Madrid to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 5% potential increase in price (£31 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease (£20 potential savings vs. average return price).
Search Deals
Average for round-trip flights in April 2025
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Find flight deals from Madrid to Santa Cruz de la Sierra

Cheapest flights from Madrid to Santa Cruz de la Sierra
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 18 April 2025.

Thu 23/1013:00MAD - VVI
1 stop21h 35mLATAM Airlines
Mon 17/1105:20VVI - MAD
1 stop30h 05mLATAM Airlines
Deal found 17/4£673
Fri 6/609:40MAD - VVI
1 stop22h 10mAvianca
Thu 12/602:55VVI - MAD
1 stop22h 45mAvianca
Deal found 17/4£702
Thu 23/1013:00MAD - VVI
1 stop21h 35mMultiple Airlines
Mon 17/1117:20VVI - MAD
2 stops18h 05mMultiple Airlines
Deal found 17/4£758
Wed 22/1014:40MAD - VVI
Nonstop11h 00mBoA
Mon 17/1121:15VVI - MAD
Nonstop11h 40mBoA
Deal found 17/4£895
Fri 31/1011:05MAD - VVI
2 stops39h 39mUnited Airlines
Mon 17/1100:55VVI - MAD
2 stops26h 10mUnited Airlines
Deal found 17/4£982

Cheapflights Fare Finder

Customise your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 18 April 2025.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.

Fly from

Madrid

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Fri 6/6

09:40-01:50

1 stop22h 10m

Santa Cruz de la Sierra Viru Viru Intl

Thu 12/6

02:55-07:40

1 stop22h 45m

£702

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Sun 14/9

06:00-01:50

2 stops25h 50m

Santa Cruz de la Sierra Viru Viru Intl

Sun 28/9

13:10-18:45

2 stops23h 35m

£875

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Fri 12/9

11:15-22:25

2 stops41h 10m

Santa Cruz de la Sierra Viru Viru Intl

Tue 14/10

01:09-09:00

2 stops25h 51m

£983

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Fri 6/6

23:55-10:29

3 stops40h 34m

Santa Cruz de la Sierra Viru Viru Intl

Fri 13/6

05:20-11:15

2 stops23h 55m

£1,494

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Fri 16/5

21:00-02:30

Nonstop11h 30m

£406

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Fri 16/5

09:40-01:50

1 stop22h 10m

£418

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Wed 30/4

11:15-22:13

2 stops40h 58m

£508

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Thu 15/5

01:45-08:30

2 stops36h 45m

£519

Flights are sorted by cheapest return flights first.

Deals found on 17/4

Best time to book a flight from Madrid to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra

How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a return flight from Madrid to Santa Cruz de la Sierra. Price data was last updated on 11 April 2025.

The price you pay for your flight from Madrid to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 68 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest time of day to fly from MAD to VVI?

Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 18 April 2025.

It’s typically best to fly out from Madrid to Santa Cruz de la Sierra in the afternoon. Doing so could potentially save you 32% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated 18 April 2025.
LATAM Airlines
7.5
Good
1,764 reviews
Check prices

Food

6.7

Comfort

7.4

Entertainment

7.0

Boarding

7.6

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.
LATAM Airlines
7.5
Good
1,764 reviews
LATAM Airlines
7.5
Good
1,764 reviews
Check prices

Food

6.7

Comfort

7.4

Entertainment

7.0

Boarding

7.6

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.
United Airlines
7.4
Good
8,667 reviews
LATAM Airlines
7.5
Good
1,764 reviews
Check prices

Food

6.7

Comfort

7.4

Entertainment

7.0

Boarding

7.6

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.
BoA
6.7
Okay
133 reviews
LATAM Airlines
7.5
Good
1,764 reviews
Check prices

Food

6.7

Comfort

7.4

Entertainment

7.0

Boarding

7.6

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.
Avianca
6.7
Okay
2,317 reviews
LATAM Airlines
7.5
Good
1,764 reviews
Check prices

Food

6.7

Comfort

7.4

Entertainment

7.0

Boarding

7.6

Overall

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.

Related info for your journey

Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Madrid to Santa Cruz de la Sierra flight route?

    The Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flight path was viewed by 12 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Madrid to Santa Cruz de la Sierra round-trip?

    Avianca, at £702, was found to be the cheapest airline from Madrid to Santa Cruz de la Sierra.Alternate airlines flying return to your destination include United Airlines and LATAM Airlines. Users have found that Avianca is 8% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Madrid to Santa Cruz de la Sierra one-way?

    £406 is the cheapest one-way deal found within the past few days, from BoA. You may also be able to find cheap deals on Avianca and United Airlines, with prices starting from £418 and £508, respectively.

  • Can I find deals for flights from Madrid to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Madrid to Santa Cruz de la Sierra flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Madrid to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Madrid to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Madrid to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
Madrid to La Paz flights

Top 4 airlines flying from Madrid to Santa Cruz de la Sierra

Discover the top 4 airlines that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 18 April 2025.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest£534Average£652FlexibilityNo cancel feeOn-time83%
Search Air Europa flights
AviancaCheapest£543Average£651FlexibilityNo cancel feeOn-time71%
Search Avianca flights
BoACheapest£560Average£746FlexibilityNo cancel feeOn-timeN/A
Search BoA flights
IberiaCheapest£561Average£607FlexibilityNo cancel feeOn-time77%
Search Iberia flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Madrid to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Madrid to Santa Cruz de la Sierra?

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Can Cheapflights find flights from Madrid to Santa Cruz de la Sierra with no change fees?

Need flexible booking options for your flight to Santa Cruz de la Sierra from Madrid? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Madrid to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Madrid to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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