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Cheap flights from Mexico City to Santiago from £281

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 20/8. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
27 Feb — 6 Mar1
1 adult

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 22 February 2025.

Round-trip from

£424

One-way from

£281

Popular in

December

Cheapest in

August

Average price

£564

Good one-way deal

£574 or less
Copa Airlines
  • Copa Airlines
  • 29/5-4/6
  • 2 total stops
  • 36h 59m total
  • Mexico City to Santiago
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Avianca
  • Avianca
  • 20/8
  • 1 total stop
  • 12h 15m total
  • Mexico City to Santiago
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Highest demand for flights based on searches. 7% potential increase in price (£34 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
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Average for round-trip flights in February 2025
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Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 22 February 2025.

Thu 29/505:50MEX - SCL
1 stop15h 18mCopa Airlines
Wed 4/602:24SCL - MEX
1 stop21h 41mCopa Airlines
Deal found 20/2£424
Fri 14/321:45MEX - SCL
1 stop23h 14mMultiple Airlines
Sun 23/321:51SCL - MEX
1 stop16h 09mMultiple Airlines
Deal found 20/2£443
Sat 15/1110:05MEX - SCL
Nonstop8h 10mAeromexico
Fri 21/1123:25SCL - MEX
Nonstop8h 35mAeromexico
Deal found 21/2£560
Wed 12/319:50MEX - SCL
Nonstop8h 10mLATAM Airlines
Wed 26/309:10SCL - MEX
Nonstop8h 40mLATAM Airlines
Deal found 20/2£586
Mon 10/300:40MEX - SCL
1 stop20h 00mAvianca
Mon 24/300:45SCL - MEX
2 stops17h 40mAvianca
Deal found 20/2£603

Find flights from Mexico City to Santiago within your budget

Customise your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 22 February 2025.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 29/5

05:50-23:08

1 stop15h 18m

Santiago Arturo Merino Benitez

Wed 4/6

02:24-22:05

1 stop21h 41m

£424

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 14/3

21:45-23:59

1 stop23h 14m

Santiago Arturo Merino Benitez

Sun 23/3

21:51-11:00

1 stop16h 09m

£443

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 11/3

10:10-21:15

Nonstop8h 05m

Santiago Arturo Merino Benitez

Fri 28/3

23:15-04:46

Nonstop8h 31m

£571

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 12/3

19:50-07:00

Nonstop8h 10m

Santiago Arturo Merino Benitez

Wed 26/3

09:10-14:50

Nonstop8h 40m

£586

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 10/3

00:40-23:40

1 stop20h 00m

Santiago Arturo Merino Benitez

Mon 24/3

00:45-15:25

2 stops17h 40m

£603

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 20/8

14:00-04:15

1 stop12h 15m

£281

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 7/3

01:20-00:13

1 stop19h 53m

£443

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 25/3

10:10-21:15

Nonstop8h 05m

£445

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 8/5

08:55-21:15

3 stops34h 20m

£469

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 8/3

09:40-07:50

3 stops43h 10m

£945

Flights are sorted by cheapest return flights first.

Deals found on 21/2

Showing 1-10 of 11 results
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Mexico City to Santiago

Get recent, data-driven insights about flights from Mexico City to Santiago including ideal travel times, pricing trends, and more.

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a return flight from Mexico City to Santiago. Price data was last updated on 14 February 2025.

Booking 83 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £1,031). Flying from Mexico City to Santiago in December is currently the most expensive (average of £1,468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 22 February 2025.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Mexico City to Santiago

Explore weekly flight availability from Mexico City to Santiago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 22 February 2025.

The most flights from MEX to SCL are scheduled on a Monday (3 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (1 on average).

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 70.0 inches per month. June is typically the wettest month, when rainfall can reach 70.0 mm. January is typically the driest time to visit Santiago when rainfall is around 0.0 mm.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 21.0 C. Travellers hoping to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 8.0 C).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated 22 February 2025.
Read through reviews of airlines operating flights from Mexico City to Santiago, such as Copa Airlines, LATAM Airlines and Aeromexico. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,502 reviews
Check prices

Comfort

7.4

Boarding

7.8

Food

6.9

Crew

8.1

Entertainment

6.9

Overall

7.6

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Copa Airlines
7.6
Good
1,502 reviews
Copa Airlines
7.6
Good
1,502 reviews
Check prices

Comfort

7.4

Boarding

7.8

Food

6.9

Crew

8.1

Entertainment

6.9

Overall

7.6

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

LATAM Airlines
7.5
Good
1,789 reviews
Copa Airlines
7.6
Good
1,502 reviews
Check prices

Comfort

7.4

Boarding

7.8

Food

6.9

Crew

8.1

Entertainment

6.9

Overall

7.6

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Aeromexico
7.5
Good
1,769 reviews
Copa Airlines
7.6
Good
1,502 reviews
Check prices

Comfort

7.4

Boarding

7.8

Food

6.9

Crew

8.1

Entertainment

6.9

Overall

7.6

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Qantas Airways
7.4
Good
813 reviews
Copa Airlines
7.6
Good
1,502 reviews
Check prices

Comfort

7.4

Boarding

7.8

Food

6.9

Crew

8.1

Entertainment

6.9

Overall

7.6

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

United Airlines
7.4
Good
8,754 reviews
Copa Airlines
7.6
Good
1,502 reviews
Check prices

Comfort

7.4

Boarding

7.8

Food

6.9

Crew

8.1

Entertainment

6.9

Overall

7.6

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 1 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Cheapflights users have booked flights from Mexico City to Santiago round-trip from £424. Other airlines that can offer you cheap pricing are Aeromexico, from £571, and LATAM Airlines, from £586. Users have found that Copa Airlines is 14% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Mexico City to Santiago one-way?

    The cheapet airlines for a one-way flight from Mexico City to Santiago are Avianca (£281), Copa Airlines (£443), and Aeromexico (£445).

  • What are the most reliable airlines from Mexico City to Santiago?

    Consider LATAM Airlines (95%), Aeromexico (94%) or WestJet (94%) when booking your flight. These represent the most reliable airlines when flying from Mexico City to Santiago.

  • What are the cheapest flights from Mexico City to Santiago?

    Looking for the cheapest flight from Mexico City to Santiago? While on average our users pay £574, our data indicates the cheapest price to be £574. The most popular route (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), is priced around £444.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £1,031). Flying from Mexico City to Santiago in December is currently the most expensive (average of £1,468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
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Lastarria car hire

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Yes! Start tracking prices for Mexico City to Santiago flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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