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Cheap flights from Mexico City to Santiago from £226

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 30/9. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
23 Apr — 30 Apr1
1 adult

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 18 April 2025.

Round-trip from

£386

One-way from

£226

Popular in

February

Cheapest in

August

Average price

£455

Good one-way deal

£548 or less
Copa Airlines
  • Copa Airlines
  • 22/5-8/6
  • 2 total stops
  • 31h 16m total
  • Mexico City to Santiago
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Avianca
  • Avianca
  • 30/9
  • 1 total stop
  • 12h 15m total
  • Mexico City to Santiago
Search Deals
Highest demand for flights based on searches. 5% potential increase in price (£21 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£5 potential savings vs. average return price).
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Average for round-trip flights in April 2025
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Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 18 April 2025.

Thu 22/501:40MEX - SCL
1 stop15h 44mCopa Airlines
Sun 8/611:28SCL - MEX
1 stop15h 32mCopa Airlines
Deal found 18/4£386
Mon 10/1110:05MEX - SCL
Nonstop8h 10mAeromexico
Wed 26/1123:25SCL - MEX
Nonstop8h 35mAeromexico
Deal found 18/4£530
Sat 19/701:40MEX - SCL
1 stop15h 44mMultiple Airlines
Sun 20/721:55SCL - MEX
1 stop24h 20mMultiple Airlines
Deal found 17/4£4,626

Cheapflights Fare Finder

Customise your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 18 April 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 22/5

01:40-19:24

1 stop15h 44m

Santiago Arturo Merino Benitez

Sat 7/6

02:24-22:05

1 stop21h 41m

£386

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 19/7

01:40-19:24

1 stop15h 44m

Santiago Arturo Merino Benitez

Sun 20/7

21:55-20:15

1 stop24h 20m

£4,626

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 30/9

14:00-05:15

1 stop12h 15m

£226

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 28/4

02:00-22:44

1 stop18h 44m

£423

Flights are sorted by cheapest return flights first.

Deals found on 17/4

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a return flight from Mexico City to Santiago. Price data was last updated on 11 April 2025.

Booking 83 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £1,031). Flying from Mexico City to Santiago in December is currently the most expensive (average of £1,468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 18 April 2025.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 70.0 inches per month. June is typically the wettest month, when rainfall can reach 70.0 mm. January is typically the driest time to visit Santiago when rainfall is around 0.0 mm.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 21.0 C. Travellers hoping to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 8.0 C).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated 18 April 2025.
Copa Airlines
7.6
Good
1,409 reviews
Check prices

Boarding

7.8

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Overall

7.6

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
Copa Airlines
7.6
Good
1,409 reviews
Copa Airlines
7.6
Good
1,409 reviews
Check prices

Boarding

7.8

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Overall

7.6

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
Avianca
6.7
Okay
2,317 reviews
Copa Airlines
7.6
Good
1,409 reviews
Check prices

Boarding

7.8

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Overall

7.6

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 2 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • What is the cheapest airline to fly from Mexico City to Santiago round-trip?

    Cheapflights users have booked flights from Mexico City to Santiago round-trip from £386. Users have found that Copa Airlines is 18% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Mexico City to Santiago?

    Consider WestJet (86%), Aeromexico (86%) or LATAM Airlines (85%) when booking your flight. These represent the most reliable airlines when flying from Mexico City to Santiago.

  • What are the cheapest flights from Mexico City to Santiago?

    Looking for the cheapest flight from Mexico City to Santiago? While on average our users pay £548, our data indicates the cheapest price to be £548. The most popular route (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), is priced around £395.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £1,031). Flying from Mexico City to Santiago in December is currently the most expensive (average of £1,468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
Santiago Arturo Merino Benitez Airport car hire
Punta Arenas car hire
Puerto Montt car hire
Balmaceda car hire
Lastarria car hire

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

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Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Need flexible booking options for your flight to Santiago from Mexico City? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes! Start tracking prices for Mexico City to Santiago flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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